In the heat of the Andalusian afternoon, the hierarchy suffered a few changes, with some riders suffering more than others in the hot slippery conditions. One man who shined more than just literally was Takaaki Nakagami, the LCR man on a roll in Jerez and snatching top spot away from Fabio Quartararo for the final six minutes of the session. The Frenchman had to relinquish control of FP4 but his pace stayed fearsome.
Pol Espargaro kept KTM firmly in contention, three tenths off the lead in third position, ahead of the Yamahas of Maverick Vinales and Franco Morbidelli. Pecco Bagnaia was the lead Ducati in sixth place, with Aleix Espargaro much happier than in the morning in seventh spot. Brad Binder continued his excellent run in Jerez with eighth in FP4, ahead of Johann Zarco and Joan Mir, who rounded out the top ten.
Valentino Rossi and Jack Miller narrowly missed out on top ten honours and rookie Alex Marquez was not too far off either, eight tenths slower than his top Honda colleague and one hundredth of a second faster than Andrea Dovizioso. Marc Marquez continued to test his post-surgery endurance and was able to string together a handful of mid to high 1:38s on his way to 16th spot, just under one second off Nakagami.