It is hard to overstate just how important pole position is at Misano. It is a tight and tortuous track, with few opportunities to pass. Small differences in practice and qualifying become magnified during the race: the holeshot is worth its weight in gold here. Get a gap, and you can be gone. The smallest winning margin at Misano was 1.578 seconds, which was the deficit of Jorge Lorenzo to Valentino Rossi in 2014. A second of that was lost on the final straight, however, as the Italian celebrated a significant victory with a monster wheelie.
It doesn't mean that races can't be exciting. The 2014 race saw an epic battle between Rossi and Marc Márquez, which lasted half the race until the Spaniard asked too much of his front tire and crashed out. Races can be hard-fought, but eventually, one rider will wear the rest down and open an unbridgeable gap. That is easier when the rider starts in front.
The first corner is another reason that pole matters at Misano. The hard right then left combination is notorious for pile ups, and the further back you are, the more likely you are to get caught up in the melee. A front row start is your best hope of making it through unmolested, though a second row start will do at a pinch. Any further back and unless you can secrete a small bottle of nitrous somewhere on the bike in search of a rocket-assisted start, carnage awaits.